Tetraethyl orthocarbonate

　　Main use: Hydroxyl protecting reagent in organic synthesis:

　　Commonly used for the protection of hydroxyl groups in polyhydroxy compounds (such as sugars, glycols, and polyols). For example, in carbohydrate chemistry, it can react with vicinal diol structures in sugar molecules to form cyclic acetals, preventing hydroxyl groups from being destroyed in subsequent reactions (such as oxidation, alkylation). After the reaction is completed, the hydroxyl groups can be restored via acid hydrolysis.

　　Precursor for synthesizing cyclic compounds:

　　Undergoes intramolecular condensation with compounds such as diols and diamines to efficiently construct five- or six-membered cyclic structures (such as cyclic acetals, cyclic carbonates). These cyclic compounds are important intermediates for the synthesis of pharmaceuticals, fragrances, and polymer materials.

　　Other applications: Used as an ethoxylation reagent in organic synthesis to introduce ethoxy groups (\(-OC_2H_5\)) into molecules. Used in the preparation of additives for coatings and adhesives, utilizing its stability and hydrophobicity to improve product performance. Used as a solvent or reaction medium in organic synthesis due to its moderate boiling point and good compatibility with reactants.

CAS NO: 78-09-1

EC NO: 201-082-2

Molecular Formula: C₉H₂₀O₄

Molecular Weight: 192.2527

Alias: ;Tetraethyl orthocarbonate;Tetraethyl orthoformate;

Structure: